Blar i forfatter "Warren, Alessandra"

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    • Manipulating fenestrations in young and old liver sinusoidal endothelial cells 

      Hunt, Nicholas J; Lockwood, Glen P; Warren, Alessandra; Mao, Hong; McCourt, Peter Anthony; Le Couteur, David George; Cogger, Victoria Carroll (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-27)
      Fenestrations are pores within liver sinusoidal endothelial cells (LSECs) that enable the transfer of substrates (particularly insulin and lipoproteins) between blood and hepatocytes. With increasing age, there are marked reductions in fenestrations, referred to as pseudocapillarization. Currently, fenestrations are thought to be regulated by vascular endothelial growth factor and nitric oxide (NO) ...

    • The Relationship between Fenestrations, Sieve Plates and Rafts in Liver Sinusoidal Endothelial Cells 

      Svistounov, Dmitri; Warren, Alessandra; McNerney, Gregory P; Owen, Dylan M.; Zencak, Dusan; Zykova, Svetlana N; Crane, Harry; Huser, Thomas; Quinn, Ronald J.; Smedsrød, Bård; Le Couteur, David G; Cogger, Victoria C (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Fenestrations are transcellular pores in endothelial cells that facilitate transfer of substrates between blood and the extravascular compartment. In order to understand the regulation and formation of fenestrations, the relationship between membrane rafts and fenestrations was investigated in liver sinusoidal endothelial cells where fenestrations are grouped into sieve plates. Three dimensional ...